showed that insomnia in adults with AD significantly predicts worse overall health status. Ī wide range of consequences has been attributed to sleep disorders in AD patients. Consistently, AD was associated with a higher risk of developing insomnia than adults without AD in a large population-based US study. A growing literature indicated sleep disturbances as a comorbidity of AD in 33–87% of adult AD patients. Several studies have shown a positive relationship between AD manifestations, including signs and associated itching, and the severity of sleep disturbances. Intense night-time itching is typically experienced by AD patients, associated with difficulty falling asleep, frequent nocturnal and early morning awakenings, and consequent daytime sleepiness. The condition is common among children but can persist into adulthood or have adult onset, affecting 2–10% of the general adult population. Early interventions focused on treating sleep disturbances could indirectly be beneficial on mental health of patients with AD, counteracting the onset and exacerbation of anxiety and depression disorders.Ītopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by pruritus, erythema, xerosis, and lichenified lesions. The present study proposed a critical role of insomnia in predisposing adult AD patients to experience depression and anxiety. Specifically, insomnia accounted for 81.64% of the relationship between atopic eczema severity and depression, and for 81.84% of the effect of AD severity on anxiety symptoms. Insomnia fully mediated the effect of AD severity on depression and anxiety. AD symptoms, as expressed by POEM, were positively associated with insomnia, depression, and anxiety severity. Two mediation models were performed, testing the mediation effect of insomnia symptoms on the relationship between AD severity and depression (model 1) and anxiety (model 2). We evaluated self-perceived severity of AD, insomnia, depression, and anxiety symptoms using validated questionnaires: the Patient-Oriented Eczema Measure (POEM), the Insomnia Severity Index (ISI), the Beck Depression Inventory-second edition (BDI-II), and the Generalized Anxiety Disorder-7 scale (GAD-7), respectively. dev., 34.28 ± 13.07 years 27 males range 18–67 years) diagnosed with AD participated in a cross-sectional study. We tested this assumption by mediation model analyses in adult AD patients.Ī total of 57 patients (mean age ± std. A growing literature proposed a crucial role of sleep disturbances in the development of mental health problems in AD. Atopic dermatitis (AD) is a common inflammatory chronic skin disease typically associated with atopic comorbidities and other non-atopic conditions such as sleep disturbances, and mood/anxiety disorders.
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